Clomicalm in dogs

Clomicalm is primarily used for the treatment of separation anxiety in dogs. It is also know by the generic name Clomipramine. Novartis is the company that makes clomipramine both for humans and dogs. This medication can be used to treat aggression and obsessive-compulsive disorders like tail chasing in dogs.

Clomicalm in cats

Its use in cats must be done with caution because cats are more sensitive to trycyclic antidepressant drugs.

How it works

Clomipramine hydrochloride, the active ingredient of CLOMICALM, has a broad-spectrum of action in blocking the reuptake of neurotransmitters. Clomipramine hydrochloride is metabolized to clomipramine, a potent and selective serotonin (5-HT) reuptake inhibitor and to desmethyl-clomipramine a potent and selective noradrenaline reuptake inhibitor. It also has anticholinergic effects. CLOMICALM possesses anxiolytic properties and has a very limited sedative effect, thus maintaining the dog’s ability to learn new behaviors.

How is Clomicalm sold?

It is sold as prescription tablets and capsules. Oral, beef flavored tablets of 3 strengths are available:CLOMICALM 5, 20 and 80 contain 5.00 mg, 20.00 mg and 80.00 mg clomipramine hydrochloride, respectively.

Dosage and Administration

(taken from Novartis website)CLOMICALM is administered orally at a dose of 1 - 2 mg/kg clomipramine twice daily to give a total daily dose of 2 - 4 mg/kg according to the following table:

How to administer

CLOMICALM may be given with or without food. Usually, a treatment time of 2-3 months with CLOMICALM in combination with behavioral modification techniques is sufficient to control the symptoms of separation-related disorders. Some cases may require longer treatment. In cases showing no improvement after 2 months, treatment with CLOMICALM should be ceased.

Side effects possible

Side effects of clomipramine may include drowsiness, dry mouth, rapid heart rate, loss of appetite, vomiting and diarrhea. Some patients may become aggressive.

What special precautions are there

Do not use this medication in animals that are allergic to it or other tricyclic antidepressants. Use with caution in patients with liver disease, urinary retention, hyperthyroidism, seizure disorders or glaucoma. Do not use in pregnant or nursing females. Do not use in breeding males. Do not use with monoamine oxidase inhibitors (MAOIs) such as selegiline or Preventic tick collar. If the patient is being given an MAOI, wait 2 weeks after discontinuing before starting treatment with clomipramine. Do not use with other central nervous system (CNS) depressants such as barbiturates or tranquilizers. Always tell your veterinarian and pharmacist what other medications your pet is taking. Give this medication with food.

In the event of an overdose

Contact your veterinarian or veterinary emergency room. Symptoms of overdose may include convulsions, heart arrhythmia and rapid heart beat (tachycardia).

Clomipramine (Clomicalm®) is manufactured by Novartis Animal Health. Their web page details this product and includes the actual product insert.

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